I also played a bit of Supreme Commander but I didn't really like that game and I've already uninstalled it.
Supreme Commander is good because:
- Huge maps.
- Cool units.
- Strategic zoom is really helpful.
- Multiplayer.
But bad because:
- Boring maps.
- Though you can build hundreds of units, they are all so tiny...
- Repetitive missions... always the same.
Command And Conquer has:
- Kane!
- Kaaaaaane! (Yes, he counts for two points!)
- Full-motion video is back and you can't help but love the cheesy acting.
- Nice detailed maps.
- A superb engine. The maps load incredibly fast, and there is no huge framerate drop - ever! Even with a lot of units on screen... how do they do it? (Supreme Commander takes ages to load.)
- Cool units.
- Fun multiplayer.
- Did I mention Kane?
- Spectacular effects.
It does need better patching though (especially for people without high-end systems). On my system however the game ran like a dream in 1600x1200 with all options on highest (except AA, which is level 1).
However, if you adored Total Annihilation, you will like Supreme Commander. If you loved C&C, you'll love Tiberium Wars. I liked both, but I do prefer to play a game of CC3.